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pentobarbital will lower the extent or effect of brexpiprazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Double brexpiprazole dose over 1-2 weeks if administered with a powerful CYP3A4 inducer.pentobarbital will decrease the extent or effect of conjugated estrogens by impacting hepatic/intestinal enzy